Biometrika Oct 27, 2026

Test of partial effects for Fréchet regression on Bures-Wasserstein manifolds

Authors
Hongzhe Li Haoshu Xu
Research Topics
Machine Learning
Paper Information
  • Journal:
    Biometrika
  • DOI:
    10.1093/biomet/asag064
  • Published:
    October 27, 2026
  • Added to Tracker:
    Oct 27, 2026
Abstract

Abstract We propose a novel test for assessing partial effects in Fréchet regression on the Bures-Wasserstein manifold. Under the null hypothesis, we show that the statistic admits a degenerate V-statistic approximation whose limiting distribution is aweighted mixture of chi-squared random variables, with weights determined by the eigenvalues of an integral operator associated with a reproducing kernel Hilbert space (RKHS) kernel. We establish the asymptotic validity and consistency of the proposed test. Its finite-sample performance is examined through simulation studies.We apply the proposed test to study the effect of age, while controlling for other covariates, on gene co-expression structure in single-cell data.

Author Details
Hongzhe Li
Author
Haoshu Xu
Author
Research Topics & Keywords
Machine Learning
Research Area
Citation Information
APA Format
Hongzhe Li & Haoshu Xu (2026) . Test of partial effects for Fréchet regression on Bures-Wasserstein manifolds. Biometrika , 10.1093/biomet/asag064.
BibTeX Format
@article{paper1833,
  title = { Test of partial effects for Fréchet regression on Bures-Wasserstein manifolds },
  author = { Hongzhe Li and Haoshu Xu },
  journal = { Biometrika },
  year = { 2026 },
  doi = { 10.1093/biomet/asag064 },
  url = { https://doi.org/10.1093/biomet/asag064 }
}